Thursday
Nov222018

Abstract

Hmga2 inactivation suppresses the development of a melanoma phenotype in skin exposed to UVB light

Elizabeth S. Lavin, Leanne R. Donahue, Hyeongsun Moon, Luye An, Andrew C. White
College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA (Elizabeth Lavin), Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA


Hmga2 is an architectural chromatin-remodeling factor that is upregulated in many cancers, including melanoma. Previous findings suggest that Hmga2 inactivation may prevent ultraviolet B (UVB)-mediated melanoma development, potentially through changes in inflammatory infiltration. Using murine models, we investigate the role of Hmga2 in skin exposed to UVB radiation to characterize environmental changes in Hmga2 -/- skin that may inhibit early melanomagenesis. We demonstrate that moderate acanthosis occurs in wild type skin within three days following UVB exposure, and loss of Hmga2 significantly attenuates this phenotype. Specifically, time course experiments demonstrate that expansion of the basal Keratin 5 (K5) and suprabasal Keratin 10 (K10) epidermal populations are markedly reduced in Hmga2-/- skin. These findings delineate the role of Hmga2 in modifying the cutaneous microenvironment in response to UVB exposure and in early melanoma formation.

Research Grant: NIH Training Grant
Student Support: Veterinary Investigators Program, Cornell University College of Veterinary Medicine

 

This abstract was submitted by Elizabeth Lavin from Cornell University. Thanks, Elizabeth!

Wednesday
Nov212018

Staggeringly Funny

Thank you to Sophie Cressman from The Ohio State University for the following submissions to the Foot in Mouth Disease section of our blog!

 

"Story time: I went to a fall festival today and waited in line with 5 year olds to get a free balloon 'for my little sister' that I fully intend to use during my anatomy study session of the lungs tonight."

Tuesday
Nov202018

Healing Hands

Check out these peaceful photos uploaded by Shanna Wong from North Carolina State University!

ReflectionsGolden Hour

Monday
Nov192018

NAVLE Package Scholarship

NAVLE Package Scholarship
SAVMA's Education and Professional Development Committee 

Submit an essay of 250 words or less outlining the importance of dedication to lifelong learning to being a successful veterinary professional for a chance to win $300 towards a NAVLE study package of your choice from SAVMA’s EPDC Committee.

Apply here. The deadline is December 31st, 2018. You must be a SAVMA member to apply.

Wednesday
Nov142018

VetX

This amazing experience was submitted by Kristi Crow from Purdue University. Her contact info is at the bottom if you would like to contact her for more information!

This summer I spent 2 weeks on one of the best trips of my life. I went expecting to learn about wildlife medicine and MAYBE gain some hands-on experience. What I ended up leaving with was more than I could’ve imagined. I gained an immense amount of knowledge, diverse experience, new family and the goal to one day return to work in South Africa. I still can’t stop talking about this trip which is why I want to share this with you!

VetX is located against the Langeberg mountain range on the world-famous Garden Route Coast in South Africa. This is roughly 4 hours outside of Cape town and is run by Umhkondo Big-5 Wildlife Volunteering. I felt completely at home and safe the entire time I was on the trip. The accommodations and people are absolutely fantastic. The program leader, Hein, is an extremely experienced individual in wildlife (& everything else) and I honestly felt like I learned more from him than some of my classes at school. Vicky is another leader who helps with VetX but works more closely with volunteers from around the world who participate in the conservation program. She is my soul sister and one of the most genuine humans to walk this planet. I miss her every day! And I can’t forget about Madre. The woman who made sure we were all fed, taken care of, and laughing 24/7. There’s just so much to say about these individuals. I’m already planning to go back to visit them during a fourth-year block!

The VetX program incorporates lectures alongside hands-on learning which I felt was extremely helpful since I didn’t have much wildlife experience prior to this trip. Imagine sitting in lecture learning about all the different African species and then actually capturing/relocating them a day later. It doesn’t get much better than that. This program is fast paced, exhilarating, and always full of surprises. That’s what I love about wildlife medicine...you never know what’s going to happen. You must be quick, innovative, and confident for this kind of work and I LOVE it.

A lot of our first week was spent learning the background and basics of the area, different animal species, and various procedures. Usually any lecture regarding a procedure was followed with time to go out and practice that procedure. Our first activity revolved around techniques to capture and relocate Sables, an African antelope species. That very next day we were out in the “buggies” (trucks) helping the local vet and farmers capture and relocate 8 Sables. This was my first taste of wildlife medicine and it satisfied this adrenaline junkie! I had the opportunity to take TPRs, deworm, vaccinate, and help restrain during these days.

The days following involved us assisting in giraffe capture/relocations, relocating/treating Cape buffalo, darting out of helicopters, and so much more. Everyday was packed with new opportunities for us to learn about wildlife medicine and conservation. In my opinion, this experience encompassed everything I could want as someone starting out in wildlife medicine. The only downfall about this program is that it wasn’t long enough. I could’ve stayed there for months but I do plan on applying for an off-campus block to go back! So, if you’re someone that’s interested in wildlife medicine, loves traveling, or wants an adventurous veterinary experience I would 11/10 recommend this program. You will leave with so much knowledge and new friends from around the world.

This experience is structured for those who are in the veterinary field (vet students & vet nurses) and others can be considered via a Skype interview. A short list of some of the hands-on experiences include relocating animals, DNA sampling, medical treatments, measuring horn sizes, TB testing in buffalo, rhino de-horning, microchip implants, fitting collars to animals for tracking, deworming, and darting practice. If you aren’t in the veterinary field don’t fret! They also have awesome conservation programs.

If you’re interested in this program please email me at dogtorkristi@gmail.com so I can pass along your information to the Umkhondo team!