Thursday
Mar282013

Transmyocardial therapeutic-delivery using real-time MRI guidance

Entry, Abstracts
Jeremy Maurer, Penn

Fig.1 (a) Needle catheter showing microcoils and extended nitinol injection needle. (b) Portions of the heart segmented on cine stack (TR/TE=3.4/1.54ms, voxel=1.3x1.3x5 mm3, FA 43o) are used to build 3d model of the left, right ventricle and infarcted region. (c) 3D model overlaid into real-time MR images is used to (d) navigate the catheter to pre- defined injection targets. Catheter model is built from MR images of active tracking coils. (e) Injection of iron-oxide laden therapeutic into myocardium (yellow arrow) monitored under real-time MRI. TR/TE=2.8/1.19 ms, voxel=1.9x1.9x5mm3, FA/tracking FA =50o/15o, 1.5-4 frames/s. (f, g) Pre- and post- injection MRI confirms injection of microbeads. TR /TE = 6.8/3.25ms, FA=30o, voxel =1.0×1.0×5.0mm3.Hegde S, Shea S, Pan L, Karmakar P, Barbot J, Kirchberg K, Vadakkumpadan F, Maurer J, Cook J, Trayanova N, Solaiyappan M, Johnston P, Kraitchman D. Transmyocardial Therapuetic-Delivery Using Real-Time MRI Guidance. SCMR 16th Annual Scientific Sessions, San Francisco, CA, January 31 - February 3, 2013. Poster.

 

Background: Catheter-based transmyocardial injection offers a minimally invasive method to deliver therapeutics to the heart. It is typically performed under X-ray fluoroscopic guidance, which suffers from poor demarcation of myocardial boundaries and an inability to assess myocardial viability. MRI-guided intramyocardial delivery of therapeutics at 3T offers the potential for more precise targeting of these therapies with superior tissue contrast.


Our group has been actively involved with microencapsulated stem cell therapy to improve cell retention and prevent stem cell rejection. However, most microencapsulated stem cell products are too large to be administered transmyocardially. We demonstrate here intramyocardial injection of a prototype single stem cell therapeutic into the myocardium of a normal swine using real-time MR guidance and a custom active injection catheter.

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Wednesday
Mar272013

Entry, Creative Corner
Regina Shores, Virginia-Maryland

"In Memory"

 

"Sunset at the Bay"

"Untitled"

Tuesday
Mar262013

Economic Initiatives and Education Integrated Outreach (EIEIO) Grant

The SAVMA Governmental Affairs Committee and Education and Professional Development Committee are offering a grant to veterinary students and veterinary student organizations to provide funding for awareness of the current financial concerns for veterinary students.

These events may include but is not limited to: letters to government officials, invitation of government officials and/or leaders to events involving student participation, travel of students to meetings concerning budgets, webinars, or other economic education events. Economic education events could be (but are not limited to) lectures or wet-labs that educate students on managing finances and understanding current loan repayment options.

These grants, up to $1000, will be awarded to the applications which best demonstrate innovation, the potential to impact a large number of students, and accurate presentation of a topic(s) related to economic issues for veterinary students. The GAC and EPDC hope that with this grant, veterinary students will have the opportunity for exposure to current and practical topics that may not otherwise be included in the typical veterinary curriculum.

The grant application will be sent out beginning September 1st, 2013 and will be reviewed and awarded based on a first come first serve basis. Your student delegate will e-mail your school with the application, or you may check in here after the application period opens.

If you have any questions please feel free to e-mail gac.savma@gmail.com. Good luck!

Monday
Mar252013

Experience at TRC: Tambopata Research Center, Peru

This edition's Life as a Vet Student category: Each day the veterinary profession becomes less national and more global. The AVMA states, "In recent years the AVMA has turned to the global stage to advance its strategic goals, particularly in the areas of animal welfare and veterinary education, and has worked hard to ensure that the U.S. veterinary profession's voice is heard in international settings." Are you interested in global health? How have you contributed or plan to contribute in international veterinary medicine?

Entry, Life as a Vet Student
Lauren Thielen, Texas A&M University

TRC, Tambopata Research Center, is a macaw conservation research facility located in south-eastern Peru, deep within the beautiful Peruvian Amazon, along the Tambopata River. The lodge is about 100km from the closest city, Puerto Maldanado, an 8hr boat ride upriver from the town. The research is lead by Texas A&M’s Dr. Donald Brightsmith, supported by Texas A&M Veterinarians and many volunteers from throughout the world. The lodge serves as both a research facility as well as a site for ecotourists to become immersed in the Amazon.

Over Christmas I was given the unbelievable opportunity to volunteer at TRC as a veterinary student. TRC’s research is focused on the long term monitoring of macaw and parrot biology, research first began in 1999. The location of the TRC lodge is no coincidence, as it is located only a 2 minute boats ride to the clay lick. The clay lick is a huge part of the research, as it is a location where thousands of birds can be observed at once. The purpose of animals arriving at the clay lick is to ingest the sodium-rich clay not provided in their diet. Additionally, by studying the clay lick the social order and behavior of different parrot species can be observed.

Breeding season is during the rainy season, December to June, and that is when the veterinarian comes into play. Chick growth data is taken to better understand the reproductive success of both Scarlet and Red-and-green Macaws. The data sets are used to help understand the fluctuations in clay lick use related to nesting, food supply, and bird abundance. As a veterinary student I spent my days walking throughout the Amazon Rainforest to different macaw nest sites to check on the development of the chicks.

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Sunday
Mar242013

Case Report- Belgium Draft Nurse Mare with Chronic Progressive Lymphedema

Entry, Case Study
Rachel Ruden, University of Pennsylvania

History:

Lewie presented with gross lesions on both front fetlocks and a small cluster of nodules on the dorsal surface of her left hind pastern. The affected area was clearly painful. Her fetlocks were so swollen with edema it was hard to separate individual lesions, and they readily bled when manipulated. The odor and fluid attracted flies, but upon further examination, the moist spaces were also supporting colony of maggots. Finally, movement was onerous. All of these signs indicated Lewie was suffering from Chronic Progressive Lymphedema (CPL), commonly called Draft Horse Dermatitis. This is a skin disease that causes inflammation of the legs, most commonly affecting the fetlock region. Though the original insult may be a cut, the disease becomes escalated by secondary infections that produce edematous nodules that bleed and fester. Finally, ectoparasites complicate the issue, especially in mares that should not be treated with medications like Frontline while nursing. There is no cure for CPL, and due to its progressive and debilitating nature, this disease will put an early end to a horse’s career, and often, its life.

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